Hepatitis Virus Markers of the Population in the Southern Plain Region of Hungary; Perinatal And/or Transplacental Transmission of Viruses
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چکیده
HEPATITIS VIRUS MARKERS IN THE POPULATION OF THE SOUTHERN PLAIN REGION OF HUNGARY; PERINATAL OR TRANSPLACENTAL TRANSMISSION OF HUMAN VIRUSES Nation-wide programmes have been initiated in Hungary for the prevention of perinatal transmission of hepatitis B virus (HBV) in 1995 and mandatory vaccination has been initiated in 2001. The prevalence of hepatitis virus markers have been determined in the population of the Southern Plain Region of Hungary in sera collected before 2001. The behaviour of the hepatitis B X-protein and antibodies as well as HBV genotypes were also examined. These data can be used later for the control of efficacy of preventive programmes. Recently conflicting results have been published on the perinatal and transplacental transmission of viruses, therefore a systematic molecular examination of healthy pregnants and amniotic fluids taken at term were completed. Results confirmed that the preventive measures will reduce the occurrence of HBV prevalence in the age group below 20 years of age to very low level (< 1 %). It has been observed, that of X-antigens and antibodies form probably complexes in the plasma similar to other HBV-coded viral proteins. One third of the amniotic fluids at term were found to contain DNA of herpesvirus types 4, 5, 6, 7 and 8. Low levels of endotoxin and papillomaviruses could be also detected. The comparison of virus content of maternal blood and amniotic fluid suggested unequal transplacental transmission of viruses.
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تاریخ انتشار 2010